the prognostic significance of her2-neu over expression in gastric carcinomas
نویسندگان
چکیده
background: h e r2/ n eu i so n e o ftheepi de rmalg r owth f actor r e c e pt o rsfami l i e s andsee m stohaveprognosticsignificanceofsomesolid t umors.theo b jecti v eof thisstu d yistoevaluatet h epossi b ilityofher2ex p ressioningastricca n cersand the p o s si b le r e lat i o n ship o fh e r2withtumo r ’scli n icopat h o l o gicpara m e te r sa n d a l s oits pr o gno s tic r o l e . methods: thisstudyw a s p e rfor m edon100cas e sofgas t r i ccarci n omaw i thstage ibto iii(acco r dingtotnms t aging). sur v i va l,rec u rrence d ateofpatients,gra d e and lymph nodes in v o l v ement were assesse d . her 2 /neu ex p ression was det e rmi n edbyimmunohis t oc h e micalmet h odonre c e i v eds a mpleb l ock s .s u rvival of patientswith orwit h outher 2 -neu expressionwere evalu a tedbykapla n -meier methodand c o mparedwiththelo g -ranktestfollo w edbymultiv a ria t eanalysis using cox regression. results: sevencas e sw er e 3 +membra n o ush e r2 r e acti v i t y ,5ca s e s w e r e2+and 1 3 cas e s wer e 1+ ; a l s o 75 % o f ca s e s d e mo n stra t ed n oreacti v ity.regar d ing relations h ipbetweentumorgradeandmem br ano u sher2, allpatientswi t hpoorly differen t iated tumorswereher2ne g ative butpatientswithmoderate andwell differen t iated tumorhad18.1%and1 9 . 6 %her2reactivityr e s p ecti v e ly;t h ere were no significant differe n ce between grou p s s t atistically(p>0.05 ) . median overalls u rviv a lwas27.25 a nd46monthsinher2negativeandher2positi v e cas e s r e s p ect i ve l y ; the r e we r e no s i g n ificant d i f f e re nce betw e e n groups statistic a l l y a s well ( p >0.05 ) . conclusion: her2 reacti v ity h asnotrela t io n shipwithtumor gradeandly m phnode inv o lve m entaswellastumor stage.f r omtheoth e rp o intofviewno s i gnifica n t correlationisfound b e tween her2ex p ressionanddise a se frees u rvivaloro v er a ll survi v alof g a s t ric cancerpat i e nts.
منابع مشابه
The Prognostic Significance of Her2-Neu Over expression in Gastric Carcinomas
BACKGROUND Her2/neu is one of the epidermal growth factor receptors families and seems to have prognostic significance of some solid tumors. The objective of this study is to evaluate the possibility of Her2 expression in gastric cancers and the possible relationship of Her2 with tumor's clinicopathologic parameters and also its prognostic role. METHODS This study was performed on 100 cases o...
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عنوان ژورنال:
iranian journal of cancer preventionجلد ۴، شماره ۴، صفحات ۱۷۰-۱۷۶
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